蘇州昊帆生物股份有限公司

◆会社紹介

蘇州昊帆生物株式会社は、2003年に設立され、江蘇省蘇州市ハイテク区に本社を構える、グローバルな製薬研究・製造企業向けに特色ある原料・試薬を提供する中国の上場企業です。
同社の製品は、ペプチド、核酸、医薬品合成などの分野で広く活用されており、製品ラインナップには、アミド結合用縮合剤、保護剤、リンカー、抗体薬物複合体（ADC）用タンパク質架橋剤、分子ブロック、リポソーム、リン試薬など多岐にわたります。

◆製品ラインアップ

・縮合剤

品名Cas No.品名Cas No.
Benzotriazol-1-yloxy)tris(dimethylamino) phosphonium hexafluorophosphate56602-33-6Ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate137156-41-3
Bis(2-oxo-3-oxazolidinyl)phosphinic chloride68641-49-62-Pyridinol-1-Oxide13161-30-3
1,1'-Carbonyldiimidazole530-62-1Mono-methyl terephthalate1679-64-7
2-Chloro-4,6-dimethoxy-1,3,5-triazine3140-73-61-(Mesitylene-2-sulfonyl)-3-nitro-1,2,4-triazol74257-00-4
2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate101385-69-7Bis(4-nitrophenyl)carbonate5070-13-3
6-Chloro-1-hydroxibenzotriazol26198-19-6(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate156311-83-0
2-Chloro-1-methylpyridinium iodide14338-32-0Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate128625-52-5
3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one165534-43-0Bromo-tris-pyrrolidinophosphoniumhexafluorophosphate132705-51-2
N,N′-Diisopropylcarbodiimide693-13-0Chlorotripyrrolidinophosphonium hexafluorophosphate133894-48-1
2-Chloro-1,3-dimethylimidazolidinium chloride37091-73-9O-(Benzotriazol-1-yl)-N,N,N',N'-tetra methyluronium tetrafluoroborate125700-67-6
4,4'-Dimethoxytriphenylmethyl chloride40615-36-9N,N,N‘,N‘-Tetramethylchloroformamidinium-hexafluorophosphate94790-35-9
207915-99-9
4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride3945-69-5O-(6-Chloro-1-hydrocibenzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate330641-16-2
Bis(Pentafluorophenyl)Carbonate59483-84-0O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate136849-72-4
N-hydroxy-5-norbornene-2.3-dicarboxylimide21715-90-2Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate164298-23-1
1-Ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride25952-53-82-(endo-5-norbornene-2.3-dicarboxylimide)-1,1,3,3-tetramethyluronium tetrafluoroborate125700-73-4
2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline16357-59-82,4,6-triisopropylbenzenesulfonyl hydrazide6553-96-4
O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate148893-10-12,4,6-triisopropylbenzenesulfonyl azide36982-84-0
O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluorophosphate94790-37-1N,N'-Bis-Boc-1-Guanylpyrazol152120-54-2
O-(6-Chloro-1-hydrocibenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate330645-87-9Ethyl cyanoglyoxylate-2-oxime3849-21-6
1-Hydroxy-7-azabenzotriazole39968-33-7Pentafluorophenol771-61-9
N-Hydroxybenzotrizole2592-95-2Pentafluorophenyldiphenylphosphinate138687-69-1
1-Hydroxybenzotriazole hydrate123333-53-9
80029-43-2		Pentafluorophenyl Trifluoroacetate14533-84-7

・保護剤

品名Cas No.品名Cas No.
N-t-Butoxycarbonyl-amide4248-19-59-Fluorenylmethyl Carbamate84418-43-9
Tert-Butyl N-hydroxycarbamate36016-38-3Tert-Butyl 2,2,2-trichloroacetimidate98946-18-0
Boc Anhydride24424-99-5Benzyl carbamate621-84-1
Tert-Butyl carbazate870-46-2N-(Benzyloxycarbonyloxy) Succinimide13139-17-8
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile58632-95-4Di-tert-butyl iminodicarboxylate51779-32-9
Allyloxycarbonyl succinimidyl ester135544-68-2Tert-Butyl 2-(methylamino)ethylcarbamate122734-32-1
9-Fluorenylmethanol24324-17-2Di-Tert-Butyl Hydrazodicarboxylate16466-61-8
N-(9-Fluorenylmethoxycarbonyloxy)succinimide82911-69-1N-[2-(trimethylsilyl)ethoxycarbonyloxy]succinimide78269-85-9
Chloroformic acid 9-fluorenylmethyl ester28920-43-6N,N'-Disuccinimidyl carbonate74124-79-1

・分子ブロック

品名Cas No.品名Cas No.
Tris(N,N-tetramethylene)phosphoric acid triamide6415-07-2Benzophenone imine1013-88-3
(S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol22323-82-6Iodobenzene diacetate3240-34-4
1,3,5-Triisopropylbenzene717-74-8Cyclopropane-1-carboximidamide hydrochloride57297-29-7
1,3,5-Tri-tert-butylbenzene1460-02-2Di-tert-Butyl azodicarboxylate870-50-8
2,2'-Dithiodipyridine2127-03-9[Bis(trifluoroacetoxy)iodo]benzene2712-78-9
2-Mesitylenesulfonyl chloride773-64-8Benzamidine hydrochloride hydrate206752-36-5
2-Bromo-1,3,5-triisopropylbenzene21524-34-51H-Pyrazole-1-carboxamidine hydrochloride4023-02-3
N-(Diphenylmethylene)glycine ethyl ester69555-14-21,1'-(Azodicarbonyl)-dipiperidine10465-81-3
N-(Diphenylmethylene)glycine methyl ester81167-39-74-Bromobenzamidine hydrochloride55368-42-8
N-(Diphenylmethylene)glycerine tert-butyl ester81477-94-32-Bromopyridine-5-carbaldehyde149806-06-4
Diphenylmethylene-Glycine benzyl ester81477-91-0Chloroformamidine hydrochloride29671-92-9
Diphenylmethyleniminoacetonitrile70591-20-7O-(2-Mesitylenesulfonyl)acethydroxamic acid ethyl ester38202-27-6
8-Quinolinesulfonyl chloride18704-37-5N-Boc-imidazole49761-82-2
N,O-Dimethylhydroxylamine hydrochloride6638-79-5Ethyl acetohydroxamate10576-12-2
N-Boc-3-pyrrolidinone101385-93-7Isopropylhydrazine hydrochloride16726-41-3
N-Boc-1,3-propanediamine75178-96-0Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate146256-98-6
N-Boc-ethylenediamine57260-73-8N,N,N',N'-tetramethylazodicarboxamide10465-78-8
N-Benzylhydroxylamine hydrochloride29601-98-7N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride637-01-4
O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine6723-30-4N-Benzylglycine17136-36-6
O-(4-nitrobenzoyl)hydroxylamine35657-36-44-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile21642-98-8
Formamidine acetate3473-63-05-(Ethylthio)-1H-tetrazole89797-68-2
4-Aminobenzyl alcohol623-04-12-tert-butyl-1,1,3,3-tetramethyl-guanidine29166-72-1
N-Boc-1,4-butanediamine68076-36-8Tetramethylurea632-22-4

・架橋剤

品名Cas No.品名Cas No.
DL-1,4-Dithiothreitol3483-12-3Sulfosuccinimidyl-trans-4-(n-maleimidomethyl)cyclohexane-1-carboxylate92921-24-9
Isopropyl-β-D-thiogalactopyranoside367-93-16-Maleimidocaproic acid55750-53-3
N-Hydroxysulfosuccinimide sodium salt106627-54-7N-Succinimidyl 6-maleimidohexanoate55750-63-5
Tris(2-Carboxyethyl)Phosphine Hydrochloride51805-45-93-Maleimidopropionic acid7423-55-4
(+)-Biotin N-hydroxysuccinimide ester35013-72-0N-Succinimidyl maleimidoacetate55750-61-3
N-Benzylmaleimide1631-26-1N-Succinimidyl 3-maleimidopropionate55750-62-4
N-Methylmaleimide930-88-1Disuccinimidyl subera68528-80-3
N-Ethylmaleimide128-53-03,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester)57757-57-0
N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate64987-85-5

・リンカー

品名Cas No.品名Cas No.
4-(Hydroxymethyl)benzoic acid3006-96-03-Hydroxy-xanthen-9-one3722-51-8
4-(Hydroxymethyl)phenoxyacetic acid68858-21-9RAMAGE Linker212783-75-0
4-[(2,4-Dimethoxyphenyl)(Fmoc-amino)methyl]phenoxyacetic acid145069-56-3

・リン試薬

品名Cas No.品名Cas No.
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite102691-36-12-Cyanoethyl N,N-diisopropylchlorophosphoramidite89992-70-1
Bis(dimethylamino)phosphoryl chloride1605-65-8(N,N-diisopropylamino)dichlorophosphine921-26-6
Bis(2-cyanoethyl) N,N-bis(isopropyl)phosphoramidite102690-88-0Dibenzyl phosphite17176-77-1
N,N,N',N'-tetrakis(1-Methylethyl)phosphorodiamidous acid phenylmethyl ester108549-21-9

・リポソーム

品名Cas No.品名Cas No.
1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)132172-61-31,2-Dierucoyl-sn-glycero-3-phosphocholine51779-95-4
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine4004-05-11,2-Dimyristoyl-sn-glycero-3-phosphocholine18194-24-6
2-Oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine26853-31-62-Oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine26853-31-6
1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine923-61-51-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine;18:0-18:1 PC56421-10-4
1,2-dioleoyl-sn-glycero-3-phosphocholine4235-95-41,2-distearoyl-sn-glycero-3-phosphocholine816-94-4
1,2-dioleoyl-sn-glycero-3-phosphate sodium salt108392-02-51,2-dipalmitoyl-sn-glycero-3-phosphocholine63-89-8
DMG-mPEG2000160743-62-4

・PEG

品名Cas No.品名Cas No.
2,2'-oxybis-,1,1'-bis(4-methylbenzenesulfonate)7460-82-4Tetraethylene Glycol Di-p-tosylate37860-51-8
Tri(ethylene glycol) di-p-toluenesulfonate19249-03-7Boc-1-amino-3,6-dioxa-8-octanediamine153086-78-3
5,8,11-Trioxa-2-azatridecanoicacid, 13-amino-1,1-dimethylethyl ester101187-40-0Tert-butyl 2-(2-aminoethoxy)ethylcarbamate127828-22-2
[2-(2-{2-[2-(2-amino-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetic acid1143516-05-5

・新型縮合剤

品名Cas No.品名Cas No.
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium1075198-30-95-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione monohydrate1801207-37-3
N-[(5-Chloro-3-oxido-1H-benzotriazol-1-yl)-4-morpholinylmethylene]-N-methylmethanaminium
hexafluorophosphate		1082951-62-9T4P 50%(wt%) solution in ethyl acetate163755-62-2
6-Chloro-Benzotriazole-1-yl-oxy-tris-Pyrrolidino-Phosphonium Hexafluorophosphate893413-42-8T4P 50%(wt%) solution in DMF163755-62-2
[Ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinylphosphonium hexafluorophosphate153433-21-7T4P 50%(wt%) solution in Dichloromethane163755-62-2
N-methyl-N-[4-morpholinyl(3-oxido-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl) methylene]methanaminium, hexafluorophosphate958029-37-3N-(Methyl)-N-(p-toluenesulfonyl)ethynylamine1005500-75-3
Cyano-2-(hydroxyimino)acetic acid ethyl ester potassium salt158014-03-01-tert-Butyl-3-ethylcarbodiiMide1433-27-8
5-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione5417-13-01-Propanaminium-3-[(ethylcarbonimidoyl)amio]-N,N,N-trimethyl-4-methylbenzenesulfonate6179-57-3

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